Thermal Processing and Sterilization

In thermal processing calculations, Bigelow's General Method calculates total sterilization lethality $F_0$ from the time-temperature history $T(t)$ at the slowest heating point by integrating:

Options:

• (A) $F_0 = \int_0^t 10^{(T(t) - 121.1)/z} dt$, where $z = 10^\circ\text{C}$ for *C. botulinum*
• (B) $F_0 = \int T(t) dt$
• (C) $F_0 = \int \frac{dt}{T(t)}$
• (D) $F_0 = \sum T(t) / t$